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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAPPA2
All Species:
13.64
Human Site:
S840
Identified Species:
37.5
UniProt:
Q9BXP8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BXP8
NP_064714.2
1791
198539
S840
V
Y
Q
Q
W
T
E
S
R
K
P
T
P
I
P
Chimpanzee
Pan troglodytes
XP_514020
1791
198653
S840
V
Y
Q
Q
W
T
E
S
R
K
P
T
P
I
P
Rhesus Macaque
Macaca mulatta
XP_001095160
1573
175281
H675
D
T
N
P
A
P
K
H
K
S
C
G
D
P
G
Dog
Lupus familis
XP_537179
1778
195855
S831
V
Y
Q
Q
W
T
Q
S
Q
K
P
T
P
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K8
1624
181300
P726
Y
A
F
N
A
S
S
P
M
P
C
G
P
S
G
Rat
Rattus norvegicus
XP_001073420
1788
198541
S840
V
Y
Q
Q
W
S
E
S
Q
K
P
T
P
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426627
1551
171156
F653
D
C
A
E
D
G
T
F
R
Q
Y
V
H
E
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695417
1759
195473
E834
V
Y
K
T
W
V
H
E
R
K
P
T
P
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795597
1601
177169
E703
L
P
P
R
V
M
E
E
G
P
E
G
G
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
39.7
81.7
N.A.
43.6
79.4
N.A.
N.A.
57.9
N.A.
48
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
99.7
56.3
89
N.A.
60
87.2
N.A.
N.A.
68.2
N.A.
63.8
N.A.
N.A.
N.A.
N.A.
49
P-Site Identity:
100
100
0
86.6
N.A.
6.6
86.6
N.A.
N.A.
6.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
13.3
100
N.A.
N.A.
20
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
0
23
0
0
0
0
0
0
0
0
0
12
% A
% Cys:
0
12
0
0
0
0
0
0
0
0
23
0
0
0
0
% C
% Asp:
23
0
0
0
12
0
0
0
0
0
0
0
12
0
0
% D
% Glu:
0
0
0
12
0
0
45
23
0
0
12
0
0
12
0
% E
% Phe:
0
0
12
0
0
0
0
12
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
12
0
0
12
0
0
34
12
0
23
% G
% His:
0
0
0
0
0
0
12
12
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
45
0
% I
% Lys:
0
0
12
0
0
0
12
0
12
56
0
0
0
0
0
% K
% Leu:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
12
0
0
12
0
0
0
0
0
0
% M
% Asn:
0
0
12
12
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
12
12
12
0
12
0
12
0
23
56
0
67
12
56
% P
% Gln:
0
0
45
45
0
0
12
0
23
12
0
0
0
0
0
% Q
% Arg:
0
0
0
12
0
0
0
0
45
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
23
12
45
0
12
0
0
0
12
0
% S
% Thr:
0
12
0
12
0
34
12
0
0
0
0
56
0
0
12
% T
% Val:
56
0
0
0
12
12
0
0
0
0
0
12
0
23
0
% V
% Trp:
0
0
0
0
56
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
56
0
0
0
0
0
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _